Transcription profiling of Drosophila Kc167 cell line

ABSTRACT: The consitutive activation of the JAK/STAT signalling cascade is reponsible for the majority of meyoproliferative disorders in humans, a disease that is also conserved in Drosophila. A gain-of-function mutation in the Drosophila JAK kinase leads to blood cell (haemocyte) overproliferation which eventually is manifested as black melanotic tumors. Haemocyte-like Drosophila Kc167 cells were used to identify downstream target genes of the JAK/STAT pathway which may be responsible for tumour generation and progression. Experiment Overall Design: Kc167 cells were activated with the principal JAK/STAT pathway ligand Unpaired (UPD) in a time course manner. To this end, for each transcript profiling condition and time point, biological duplicates were activated with UPD or Mock conditioned media fo

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Martin Zeidler 

PROVIDER: E-GEOD-15584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress