Preadipocytes of T2DM patients display an intrinsic gene expression profile of decreased differentiation capacity

ABSTRACT: Insulin resistance and Type 2 Diabetes Mellitus (T2DM) are associated with increased adipocyte size, altered secretory pattern and decreased differentiation of preadipocytes. To identify the underlying molecular processes in preadipocytes of T2DM patients that are a characteristic of the development of T2DM, preadipocyte cell cultures were prepared from subcutaneous fat biopsies of T2DM patients and compared with age- and BMI matched control subjects. Gene expression profiling showed changed expression of transcription factors involved in adipogenesis and in extracellular matrix remodeling, actin cytoskeleton and integrin signaling genes, which indicated decreased capacity to differentiate. Additionally, genes involved in insulin signaling and lipid metabolism were down-regulated, and inf

ORGANISM(S): Homo sapiens

SUBMITTER: Carla van der Kallen 

PROVIDER: E-GEOD-15790 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress