Determination of transcriptome of SptR in group A Streptococcus during growth in human saliva

ABSTRACT: The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and infects the oropharynx, we analyzed the transcriptome of a serotype M1 strain grown in saliva. The dynamic pattern of changes in transcripts of genes [spy0874/0875, herein named sptR and sptS (sptR/S), for saliva persistence] encoding a two-component gene regulatory system of unknown function suggested that SptR/S contributed to persistence of GAS in saliva. Consistent with this idea, an isogenic nonpolar mutant strain (DeltasptR) was dramatically less able to survive in saliva compared with the

ORGANISM(S): Streptococcus sp. 'group A'

SUBMITTER: Samuel Shelburne 

PROVIDER: E-GEOD-16124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress