Expression data from human primary fibroblasts treated with Trypanosoma cruzi-conditioned medium

ABSTRACT: The intracellular pathogen Trypanosoma cruzi secretes an activity that blocks TGF-β-dependent induction of connective tissue growth factor (CTGF/CCN2). Here, we address the mechanistic basis for T. cruzi-mediated interference of CTGF/CCN2 expression by examining host cell signaling pathways and the global inhibitory effect on TGF-β-dependent gene expression. We show that the expression of a discrete subset of TGF-β-inducible genes involved in cell proliferation, wound repair, and immune regulation are blocked by the soluble T. cruzi activity, demonstrating that this parasite-derived activity has broad, but specific effects on fibroblast gene regulation. Primary human fibroblasts were treated with TGF-β, T. cruzi conditioned medium (PCM) and TGF-β/ PCM simultaneously. Untreated cells were

ORGANISM(S): Homo sapiens

SUBMITTER: Jaime Costales 

PROVIDER: E-GEOD-16416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress