A simple method to integrate different versions of Affymetrix microarrays using duplicate samples

ABSTRACT: Background: As costs decline, the size and scope of microarray experiments have increased. In multi-centre studies there is a need to ensure consistency of data pre-processing across centres. Similarly, in smaller scale studies the evolution of microarray platforms means that there is often a need to compare data generated on earlier microarrays to that generated on newer ones. It is important in such studies to ensure that platform-dependent biases are removed so that meta-analysis of different datasets can be performed reliably. In both these cases the optimal scenario is to have a small subset of samples repeated at each site or on each platform. These replicates can then be used to learn a relationship between probe intensities on the two platforms. Results: I introduce here a simpl

ORGANISM(S): Rattus norvegicus

SUBMITTER: Paul Boutros 

PROVIDER: E-GEOD-16458 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress