Transcription profiling of human Articular chondrocytes from patients with OA undergoing total knee replacement (Mankin Score >3, Ahlb??ck Score >2) and from patients undergoing ACT

ABSTRACT: Autologous chondrocyte transplantation (ACT) is a routine technique to regenerate focal cartilage lesions. However, patients with osteoarthritis (OA) are lacking an appropriate long-lasting treatment alternative, partly since it is not known if chondrocytes from OA patients have the same chondrogenic differentiation potential as chondrocytes from donors not affected by OA. Articular chondrocytes from patients with OA undergoing total knee replacement (Mankin Score >3, Ahlbäck Score >2) and from patients undergoing ACT, here referred to as normal donors (ND), were isolated applying protocols used for ACT. Their chondrogenic differentiation potential was evaluated both in high-density pellet and scaffold (Hyaff-11) cultures by histological proteoglycan assessment (Bern Score) and immunohist

ORGANISM(S): Homo sapiens

SUBMITTER: Tilo Dehne 

PROVIDER: E-GEOD-16464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress