Identification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)

ABSTRACT: Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an orthotopic xenograph model, we have noticed that GBM TICs isolated from several patients may fall into two classes of invasive behavior: nodular or diffuse. In order to identify genes responsible for the diffusive type of invasion, we have compared by genome expression analysis, cultured GBM TICs belonging to the two classes. This analysis allowed us to identify a small group of regulated genes in the diffusive type of GBM TICs. The gene ontology process of cell adhesion and the localization of th

ORGANISM(S): Homo sapiens

SUBMITTER: Massimiliano Monticone 

PROVIDER: E-GEOD-16805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress