Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus, Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain, Glioblastoma Cell
DISEASE(S): Glioblastoma
SUBMITTER: Roberta Noberini
LAB HEAD: Tiziana Bonaldi
PROVIDER: PXD025781 | Pride | 2022-04-14
REPOSITORIES: Pride
Faletti Stefania S Osti Daniela D Ceccacci Elena E Richichi Cristina C Costanza Brunella B Nicosia Luciano L Noberini Roberta R Marotta Giulia G Furia Laura L Faretta Mario R MR Brambillasca Silvia S Quarto Micaela M Bertero Luca L Boldorini Renzo R Pollo Bianca B Gandini Sara S Cora Davide D Minucci Saverio S Mercurio Ciro C Varasi Mario M Bonaldi Tiziana T Pelicci Giuliana G
Science translational medicine 20211208 623
Glioblastoma (GBM) is a fatal tumor whose aggressiveness, heterogeneity, poor blood-brain barrier penetration, and resistance to therapy highlight the need for new targets and clinical treatments. A step toward clinical translation includes the eradication of GBM tumor-initiating cells (TICs), responsible for GBM heterogeneity and relapse. By using patient-derived TICs and xenograft orthotopic models, we demonstrated that the selective lysine-specific histone demethylase 1 inhibitor DDP_38003 (L ...[more]