Dissociated avian utricle sensory epithelia treated with one of various siRNAs or small molecule inhibitors

ABSTRACT: The inner ear utilizes sensory hair cells as mechano-electric transducers for sensing sound and balance. In mammals, these sensory hair cells lack the capacity for regeneration and if damaged lead to hearing or balance disorders. However, non-mammalian vertebrates such as birds maintain their regenerative abilities throughout their life. In a previous study we conducted a gene expression profiling time course of regenerating sensory epithelia (SE) in avian cochlea and utricle on a custom transcription factor microarray following damage by both laser and chemical ablation. We identified several known signaling cascades such as The Pax-Eya-Six-Dach pathway, Ap-1 pathway, the Tgf-β pathway and sonic hedgehog signaling that are differentially expressed during SE regeneration. In this study we

ORGANISM(S): Gallus gallus

SUBMITTER: David Alvarado 

PROVIDER: E-GEOD-16842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress