Identification of sigB inhibitors in L. monocytogenes

ABSTRACT: The extensively studied intracellular pathogen, L. monocytogenes, is an ideal model for identifying small-molecule agents for treating bacterial infections. By selecting specific biological targets in L. monocytogenes, which are common to Gram-positive pathogens, we could extrapolate drug discovery information derived from this well-studied bacterium. Attenuating the pathogenM-bM-^@M-^Ys virulence and stress response attributes without killing it, eliminates selective pressure caused by disruption of essential gene functions (as done by current antibiotics) and reduces the likelihood of developing microbes that are impervious to the effects of antibiotics. To this end, we have assessed multiple libraries of small organic compounds to identify inhibitors of L. monocytogenes M-OM-^CB, the al

ORGANISM(S): Listeria monocytogenes 10403S

SUBMITTER: M. Palmer 

PROVIDER: E-GEOD-16887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress