MiR-31 inhibits lymphatic lineage-specific differentiation in vitro and lymphatic vessel development in vivo

ABSTRACT: The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses and promotes cancer metastasis. MicroRNAs (miRNAs) have recently emerged as key and potent regulators of the genome that control virtually all aspects of cell and organism biology. Surprisingly, the physiological importance and functional activities of miRNAs in the lymphatic vascular system have not been explored. To address this, we first defined the in vitro miRNA expression profiles of primary human lymphatic endothelial cells (LECs) and blood vascular endothelial cells (BVECs). Comparative analysis of these profiles identified 4 BVEC-signature and 2 LEC-signature miRNAs. Further expression analysis by quantitative real-time PCR analysis and by in situ hybridization (ISH) studies c

ORGANISM(S): Homo sapiens

SUBMITTER: Deena Pedrioli 

PROVIDER: E-GEOD-16908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress