Genome-wide analysis of murine cardiomyocytes at different developmental stages

ABSTRACT: Cardiomyocytes exhibit differential growth patterns throughout development. In fetal life the increase in cardiac mass is associated with hyperplastic growth and cardiomyocyte proliferation. The majority of fetal cardiomyocytes are also mononucleated. During the early neonatal period in mice there is a switch from hyperplastic to hypertrophic growth of cardiomyocytes. This period is characterized by bi-nucleation and polyploidization of cardiomyocyte nuclei and a decreased capacity for cardiomyocytes to proliferate and complete cytokinesis. Increases in myocardial mass occur predominantly via hypertrophic growth. Adult mammalian cardiomyocytes are generally accepted to have little or no proliferative capacity and to be terminally withdrawn from the cell cycle. The vast majority of adult mu

ORGANISM(S): Mus musculus

SUBMITTER: Annica Pontén 

PROVIDER: E-GEOD-17020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress