Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)
TISSUE(S): Heart
SUBMITTER: Aaron Robitaille
LAB HEAD: Hannele Ruohola-Baker
PROVIDER: PXD011791 | Pride | 2022-02-15
REPOSITORIES: Pride
Miklas Jason W JW Levy Shiri S Hofsteen Peter P Mex Diego Ic DI Clark Elisa E Muster Jeanot J Robitaille Aaron M AM Sivaram Gargi G Abell Lauren L Goodson Jamie M JM Pranoto Inez I Madan Anup A Chin Michael T MT Tian Rong R Murry Charles E CE Moon Randall T RT Wang Yuliang Y Ruohola-Baker Hannele H
iScience 20211206 1
Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte de-differentiation and proliferation. However, a molecular mechanism of why these cardiomyocytes can re-enter cell cycle is poorly understood. Here, we identify a unique metabolic state that primes adult zebrafish and neonatal mouse ventricular cardiomyocytes ...[more]