Parasite strain-specific pathogenesis in murine infections with Trypanosoma brucei

ABSTRACT: Different strains of T. brucei induce different degrees of pathology in infected animals, and TREU927-infected mice display greater splenomegaly and anaemia than 247-infected mice. The analysis of differential host gene expression in infected spleens has allowed the identification of which pathways or processes are crucial in determining the progression of disease, for example IL10, LXR/RXR activation and alternative macrophage activation. We used microarray analysis to examine host gene expression between uninfected and infected mice, and between mice infected with the two trypanosome strains. Mouse spleens were dissected from infected or uninfected mice 10 days post infection, when the differences in pathology criteria (hepatomegaly, red blood cell numbers, reticulocyte percentage, IL10,

ORGANISM(S): Mus musculus

SUBMITTER: Liam Morrison 

PROVIDER: E-GEOD-17049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress