Transcription profiling of mouse and human c-MYC-transformed lymphomas reveals IKK2/NF-kB-pathway suppresses MYC-induced lymphomagenesis

ABSTRACT: Abstract. Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematological malignancies enhanced NF-kB exerts prosurvival functions. Here we investigated the role of NF-kB in mouse and human c-MYC-transformed lymphomas. The NF-kB-pathway is extinguished in murine lymphoma cells and extrinsic stimuli typically inducing NF-kB activity fail to activate this pathway. Genetic activation of the NF-kB pathway induces apoptosis in these cells, while inhibition of NF-kB by an IkBa superrepressor provides a selective advantage in vivo. Furthermore, in human Burkitt´s lymphoma cells we find that NF-kB activation induces apoptosis. NF-kB upregulates Fas and predisposes to Fas-induced cell death, which is caspase 8 mediated and can be preve

ORGANISM(S): Homo sapiens

SUBMITTER: Kay Klapproth 

PROVIDER: E-GEOD-17129 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress