Dataset Information
Transcription profiling of human fat biopsies from subcutaneous adipose tissue from unrelated individuals - a systems genetics approach implicates USF1, FADS3 and other causal candidate genes for familial combined hyperlipidemia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Christopher Plaisier
PROVIDER: E-GEOD-17170 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.
PLoS genetics 20090911 9
We hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and we investigated this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia. We first associated rs3737787 genotypes in Mexican Familial Combined Hyperlipidemia (FCHL) case/control fat biopsies, with global expression patterns. To identify sets of co-expressed genes co-re ...[more]
