A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.

ABSTRACT: We hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and we investigated this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia. We first associated rs3737787 genotypes in Mexican Familial Combined Hyperlipidemia (FCHL) case/control fat biopsies, with global expression patterns. To identify sets of co-expressed genes co-regulated by similar factors such as transcription factors, genetic variants, or environmental effects, we utilized weighted gene co-expression network analysis (WGCNA). Through WGCNA in the Mexican FCHL fat biopsies we identified two significant Triglyceride (TG)-associated co-expression modules. One

SUBMITTER: Plaisier CL 

PROVIDER: S-EPMC2730565 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature