Polidocanol injury wildtype versus Myd88 KO trachea

ABSTRACT: Nf-kB activity is associated with the key pathological features of chronic respiratory diseases including epithelial remodelling, excess mucous production, and submucosal gland hyperplasia. However, the role of Nf-kB activity in airway epithelial differentiation remains controversial. In the present study we demonstrate that Nf-kB adaptor protein Myd88 deficiency promotes increased airway submucosal gland abundance and abnormal epithelial differentiation in proximal adult airways. Abnormal airway differentiation was not developmentally determined, became exacerbated following acute lung injury, and did not involve altered epithelial proliferation or apoptosis. Instead, we demonstrate that tracheal Myd88 deficiency promotes upregulation of a unique gene expression profile that includes

ORGANISM(S): Mus musculus

SUBMITTER: Adam Giangreco 

PROVIDER: E-GEOD-17268 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress