Transcriptional profiling of cytokines and its receptors in primary murine lymphoblastoid cells (pML cells)

ABSTRACT: Transcriptional profiling of cytokines and its receptors in primary murine lymphoblastoid cells (pML cells), which are lymphomatous cells from HTLV-1 TAX transgenic mice. ATL is a T-cell malignancy caused by HTLV-I, and presents as an aggressive leukemia with characteristic widespread leukemic cell infiltration into visceral organs and skin. The molecular mechanisms associated with leukemic cell infiltration are poorly understood. We have employed mouse models of ATL to investigate the role of chemokines in this process. Transfer of splenic lymphomatous cells from transgenic to SCID mice rapidly reproduces a leukemia and lymphoma which is histologically identical to human disease. It could be shown that lymphomatous cells exhibit specific chemotactic activity in response to SDF-1α. Lympho

ORGANISM(S): Mus musculus

SUBMITTER: Hideki Hasegawa 

PROVIDER: E-GEOD-17341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress