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Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model

ABSTRACT: Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K/Akt and JAK/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key genes SDF-1/CXCR4 selected through machine learning and a protein-protein interaction network established. A chronic stress mouse model was created, with injections of SDF-1 and AMD3100 administered to observe hair growth, weight changes, and behavioral alterations and validate hair follicle activity

ORGANISM(S): Mus Musculus

SUBMITTER: Changmin Lin

PROVIDER: PXD056932 | iProX | Fri Oct 18 00:00:00 BST 2024

REPOSITORIES: iProX

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Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model.

Zhao Yinglin Y Liang Wenzi W Liu Zhehui Z Chen Xiuwen X Lin Changmin C

Biomolecules 20240925 10

Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K/Akt and JAK/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key ge ...[more]

PMID: 39456139

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