Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933

ABSTRACT: RpoS is a conserved stress regulator that plays a critical role in survival under stress conditions in Escherichia coli and other γ-proteobacteria. RpoS is also involved in virulence of many pathogens including Salmonella and Vibrio species. Though well characterized in non-pathogenic E. coli K12 strains, the effect of RpoS on transcriptome expression has not been examined in pathogenic isolates. E. coli O157:H7 is a serious human enteropathogen, possessing a genome 20% larger than that of E. coli K12, and many of the additional genes are required for virulence. The genomic difference may result in substantial changes in RpoS-regulated gene expression. To test this, we compared the transcriptional profile of wild type and rpoS mutants of the E. coli O157:H7 EDL933 type strain. The rpoS mut

ORGANISM(S): Escherichia coli O157:H7 EDL933

SUBMITTER: Herb Schellhorn 

PROVIDER: E-GEOD-17420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress