Age-related para-inflammation in the neuroretina of the mouse

ABSTRACT: To understand the age-related retinal gene changes, gene transcription profiles of neural retinal tissues from young adult (3-month) mice and old (20-month) mice were investigated by microarray. With age, 632 genes were up-regulated and 429 genes were down-regulated in the retina. Functional annotation showed that genes linked to immune responses and to tissue stress/injury responses were most modified by old age. Significant numbers of gene involved in the innate immune response including leukocyte activation, chemotaxis, endocytosis, complement activation, phagocytosis and myeloid cell differentiation were up-regulated and only a few were down-regulated. Increased microglial and complement activation in the aging retina was further confirmed by confocal microscopy of retinal tissues. The

ORGANISM(S): Mus musculus

SUBMITTER: Heping Xu 

PROVIDER: E-GEOD-17423 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress