VTA neurons show an adaptive transcriptional response to MPTP which differs from SN neurons

ABSTRACT: Implications for neuroprotection in Parkinson's disease Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum show selective vulnerability, while neighboring DA neurons of the ventral tegmental area (VTA) are relatively spared from degeneration. This pattern of cell loss is mimicked in humans, primates, and certain rodents by the neurotoxin MPTP. In this study, we aimed to test the hypothesis that there are factors in the VTA that are potentially neuroprotective against MPTP and that these factors change over time. We have found a differential transcriptional response within the cells of the SN and VTA

ORGANISM(S): Mus musculus

SUBMITTER: Sudarshan Phani 

PROVIDER: E-GEOD-17542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress