A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome

ABSTRACT: An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. Methods: C57BL/6J mice were fed a palm oil-based low fat diet (LFD) or high fat diet (HFD) for eight weeks. Microarray analysis was performed by using two complementary strategies: (1) 8-week HFD transcriptome versus 8-week LFD transcriptome and (2) transcriptome of mice sacrificed at the start of the i

ORGANISM(S): Mus musculus

SUBMITTER: Janneke de Wilde 

PROVIDER: E-GEOD-17576 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress