Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT) and macrophage-specific Bnip3 knockout (MKO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)

ABSTRACT: Obesity induces phenotypic changes and pro-inflammatory polarization of adipose tissue macrophages, contributing to chronic inflammation and insulin resistance. This study investigates the influence of Bnip3 on adipose tissue inflammation and the metabolic dysfunction prompted by a high-fat diet. Our objective involves examining the impact of a 12-week HFD feeding on both WT and Bnip3 MKO mice, comparing the differentially regulated genes based on dietary intake.

ORGANISM(S): Mus musculus

PROVIDER: GSE280875 | GEO | 2025/04/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT) and macrophage-specific Bnip3 knockout (MKO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)

Project description:Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT) and macrophage-specific Bnip3 knockout (MKO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)

| PRJNA1180959 | ENA

Nanostring of gene expression in intrahepatic leukocytes from wild type (WT) or myeloid-specific RAGE knockout (RAGE-MKO) mice fed a chow or high-fat, -fructose, and -cholesterol (FFC) diet

Project description:Intrahepatic macrophages in nonalcoholic steatohepatitis (NASH) are heterogenous and include proinflammatory recruited monocyte derived macrophages. RAGE is expressed on macrophages and can be activated by damage associated molecular patterns (DAMPs) upregulated in NASH, yet the role of macrophage-specific RAGE signaling in NASH is unclear. Therefore, we hypothesized that a subset of RAGE expressing macrophages are proinflammatory and mediate liver inflammation in NASH. We profiled the transcriptome of intrahepatic leukocytes in a murine model of diet induced NASH in WT and RAGE-MKO mice. By Nanostring nCounter Immunology Codeset Analysis of IHLs, we observed that myeloid-specific RAGE deletion resulted in amelioration of activation of macrophage and T cell pathways which was associated with attenuation of liver inflammation.

2023-09-15 | GSE243294 | GEO

RNA-sequencing of adipocyte and stromal vascular cells (SVCs) of epididymal and inguinal adipose tissue from normal chow diet (NCD)-fed mice

Project description:In mammals, white adipose tissues are largely divided into visceral epididymal adipose tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic properties. To investigate molecular mechanisms underlying depot-specific metabolic roles, we report the transcriptomes of adipocytes and SVCs derived from NCD-fed mouse epididymal adipose tissue (EAT) or inguinal adipose tissues (IAT).

2021-12-31 | GSE168906 | GEO

Transcriptomics profiling of white adipose tissue of macrophage-specific Gja1 Knockout mice fed a normal chow diet (NCD) and high fat diet (HFD)

Project description:Adipose mRNA profiles of wild-type and Gja1 knockout (tamoxifen-induced Csf1r-CreER/ Gja1(floxed/floxed)) mice were generated by deep sequencing.

2022-06-01 | GSE204794 | GEO

Transcriptomics profiling of white adipose tissue of wildtype (WT) mice fed a normal chow diet (NCD) or high-fat diet (HFD)

Project description:Adipose tissue is a crucial metabolic organ maintaining energy homeostasis via catabolic and anabolic metabolism. As high-fat diet feeding leads to metabolic dysfunction, here, we aimed to study the effect of 8 weeks of high-fat diet feeding on WT mice and compare genes differentially regulated depending on the type of diets intaking.

2021-08-30 | GSE182930 | GEO

Transcriptomics profiling of white adipose tissue of wildtype (WT) and miR-10a knockout (KO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)

Project description:Adipose tissue remodeling is a dynamic process that involves adipocyte death and turnover. This study investigates the influence of miR-10a-5p on the remodeling of adipose tissue and the metabolic dysfunction prompted by a high-fat diet. Our objective involves examining the impact of a 16-week HFD feeding on both WT mice and miR-10a KO mice, comparing the genes that are differentially regulated based on the dietary intake.

2024-09-01 | GSE260771 | GEO

Effect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice.

Project description:For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Quadriceps femoris muscles were harvested from 22-month-old muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls. mRNA levels in ATF4 mKO muscles were normalized to levels in littermate control muscles.

2015-09-03 | E-GEOD-72658 | biostudies-arrayexpress

Gonadal Adipose Tissue Profiling In HMDP (high-fat/high-sucrose diet)

Project description:Identify genes in the gonadal adipose tissue whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Parks et al Cell Metabolism 2015. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness. GWAS for expression of gonadal adipose tissue in inbred strains fed chow diet for 8 weeks followed by high-fat/high-sucrose diet 8 weeks

2015-01-08 | E-GEOD-64768 | biostudies-arrayexpress

RNA-seq of muscles from young and aged ATF4 mKO mice and littermate controls

Project description:To investigate the roles of ATF4 in skeletal muscle aging we generated muscle-specific ATF4 knockout (ATF4 mKO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of tibialis anterior muscles at 6-months and 22-months of age.

2023-05-02 | GSE212675 | GEO

Global brown adipose transcript data from fasted male BXD strains on chow diet

Project description:Transcript data from brown adipose tissue from fasted-state male BXD strains on chow or high fat diet We used microarrays to compare the brown adipose expression differences across males from the BXD strain family and across two diverse diets 29-week-old male mice were fasted overnight (6pm-9am), anesthetized under isoflurane, and perfused, then brown adipose tissue was snap-frozen in liquid nitrogen for RNA extraction and RNEasy cleanup. Each dietary and strain cohort consisted of ~5 animals which were prepared independently then pooled evenly by M-BM-5g RNA before the Affymetrix arrays were run.

2014-09-26 | E-GEOD-60150 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data