Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling by array of mouse motor nerve-stimulated and the contralateral control tabialis anterior muscles

ABSTRACT: Exercise induces skeletal muscle adaptation, and the p38 mitogen-activated protein kinase signaling pathway is thought to play an important role in the adaptive processes. We have obtained new evidence that the gamma isoform of p38 is required for exercise-induced metabolic adaptation in skeletal muscle; however, the neuromuscular activity-dependent target genes of p38gamma remain to be defined. We used microarrays to detail the global programme of gene expression underlying the skeletal muscle genetic reprogramming in response to increased contractile activity and identified distinct classes of up-regulated genes during this process that are dependent on the functional activity of the p38gamma isoform. Skeletal muscle-specific p38gamma knockout mice and the wild type littermates are subject to motor nerve stimulation of one of the tibialis anterior muscles followed by microarray analysis of both the stimulated and the contralateral control muscles.

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Pogozelski 

PROVIDER: E-GEOD-17620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.

Pogozelski Andrew R AR   Geng Tuoyu T   Li Ping P   Yin Xinhe X   Lira Vitor A VA   Zhang Mei M   Chi Jen-Tsan JT   Yan Zhen Z  

PloS one 20091120 11

Regular endurance exercise induces skeletal muscle contractile and metabolic adaptations, conferring salutary health benefits, such as protection against the metabolic syndrome. The plasticity of skeletal muscle has been extensively investigated, but how the adaptive processes are precisely controlled is largely unknown. Using muscle-specific gene deletion in mice, we now show that p38gamma mitogen-activated protein kinase (MAPK), but not p38alpha and p38beta, is required for endurance exercise-  ...[more]

Similar Datasets

Transcriptomics Expression data from motor nerve-stimulated and the contralateral control tabialis anterior muscles in mice
2010-01-07 | GSE17620 | GEO
Transcriptomics PGC-1α isoform heterodimerization restricts transcription factor docking and limits metabolic adaptations in skeletal muscle
2022-05-21 | GSE203299 | GEO
Proteomics Molecular control of endurance training adaptation in mouse skeletal muscle
2023-06-19 | MSV000092203 | MassIVE
Proteomics Profiling carbonylated proteins in heart and skeletal muscle mitochondria from trained and untrained mice
2022-02-24 | PXD003982 | Pride
Transcriptomics Transcriptomic analysis of porcine muscle Biceps femoris (BF) exposed to a single bout of endurance exercise
2012-07-12 | E-GEOD-30013 | biostudies-arrayexpress
Transcriptomics Transcriptomic analysis of porcine muscle Longissimus dorsi (LD) exposed to a single bout of endurance exercise
2012-07-12 | E-GEOD-30014 | biostudies-arrayexpress
Transcriptomics Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
2019-02-16 | GSE120862 | GEO
Transcriptomics The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism
2018-11-30 | GSE115226 | GEO
Transcriptomics Transcriptomic analysis of porcine muscle Longissimus dorsi (LD) exposed to a single bout of endurance exercise
2012-07-13 | GSE30014 | GEO
Transcriptomics Transcriptomic analysis of porcine muscle Biceps femoris (BF) exposed to a single bout of endurance exercise
2012-07-13 | GSE30013 | GEO