Transcription profiling of neocortical fast-spiking GABAergic interneurons

ABSTRACT: Fast-spiking (FS) interneurons are important elements of neocortical circuitry that constitute the primary source of synaptic inhibition in adult cortex and impart temporal organization on ongoing cortical activity. The highly specialized intrinsic membrane and firing properties that allow cortical FS interneurons to perform these functions are attributable to equally specialized gene expression, which is ultimately coordinated by cell-type-specific transcriptional regulation. Although embryonic transcriptional events govern the initial steps of cell-type specification in most cortical interneurons, including FS cells, the electrophysiological properties that distinguish adult cortical cell types emerge relatively late in postnatal development, and the transcriptional events that driv

ORGANISM(S): Mus musculus

SUBMITTER: Ken Sugino 

PROVIDER: E-GEOD-17806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress