Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

ABSTRACT: Human embryonic stem cells share identical genomic sequences with other lineage-committed cells yet possess the remarkable properties of self-renewal and pluripotency. It has been proposed that epigenetic regulatory mechanisms, involving DNA methylation and various chromatin modifications, are at least partly responsible for the distinct cellular properties between different cell types. Previous studies focusing largely on gene promoters and CpG islands have identified close association between several chromatin modifications and DNA methylation, but revealed a relatively small degree of differences between pluripotent and lineage-committed cells. Here, we examine the association between 11 chromatin modifications and DNA methylation at high resolution throughout the genome in the human e

ORGANISM(S): Homo sapiens

SUBMITTER: Bing Ren 

PROVIDER: E-GEOD-17917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress