Transcription profiling of human reintal pigment epithelial cells and activated T-cells cultured alone or together

ABSTRACT: Background: Age-related macular degeneration (AMD) is caused by the degeneration of the macular photoreceptors. This is preceded by development of subretinal protein aggregates (drusen) and degeneration of the macular retinal pigment epithelium (RPE). The underlying pathogenesis remains unknown, but the immune system is suspected to play a key role in it. Aging of the immune system, immunosenescence, includes changes in T cell sub-populations and results in low-level chronic inflammation. Because AMD exclusively occurs in patients over 55 years of age, we hypothesize that aging of the T cell compartment may be implicated in AMD pathogenesis. Methodology and principal findings: Using an in vitro co-culture system, we investigated the effects of activated T cells on a human RPE cell line (A

ORGANISM(S): Homo sapiens

SUBMITTER: Lasse Folkersen 

PROVIDER: E-GEOD-17938 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress