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SHEF1.3-derived retinal pigment epithelium for cell therapy is free of stem cell contaminants

ABSTRACT: Safety is the principle consideration with any clinical program, for which hESC and their derived products hold specific challenges. Differentiated cell products derived from hESC must be free from pluripotent cells as these could potentially form teratomas. One relevant clinical program is transplantation of retinal pigment epithelial cells (RPE) derived from hESC. This has potential for halting visual decline in conditions where the RPE layer is damaged such as age-related macular degeneration (AMD). In this study we show that whole genome gene expression analysis of SHEF1.3 starting material and the P0 pigmented RPE foci shows that the two cell types are distinct.

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Gutteridge

PROVIDER: E-MTAB-4154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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