Hoxd genes and fiber type-specific markers specify adult mouse muscle type in a diet-independent way

ABSTRACT: Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are identified that are involved in the generation of more oxidative muscle types. In the present study we searched for novel genes that are involved in specifying different muscle types. Methods: Gastrocnemius and quadriceps muscles were dissected from 20-week old C57BL/6J mice. Gene expression profiles were compared at the level of the whole-transcriptome. The diet-sensitivity of genes differentially expressed between muscle types was explored by comparing mice fed a low fat diet with mice fed a high f

ORGANISM(S): Mus musculus

SUBMITTER: Janneke de Wilde 

PROVIDER: E-GEOD-18127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress