Transcription profiling of human breast cancer cell lines treated with testosterone and testosterone-BSA conjugate

ABSTRACT: The role of androgen in breast cancer development is not fully understood although androgen receptors (AR) have been identified in breast cancer clinical samples and cell lines. However the whole spectra of androgen actions cannot be accounted to the classic AR mode of action and the possible existence of a cell surface AR has been suggested. Indeed androgens like all steroids have been reported to trigger membrane initiated signaling activity and exert specific actions. Androgens acting on the membrane can rapidly activate kinase signaling pathways and ultimately could affect gene expression. However, the molecular nature of membrane androgen binding sites represents another major persisting question. In the present study, we investigated early transcriptional effects of testosterone and

ORGANISM(S): Homo sapiens

SUBMITTER: George Notas 

PROVIDER: E-GEOD-18146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress