Transcription profiling of mouse dendritic cells treated with Lactobacillus acidophilus to investigate the induction of virus immune defense genes

ABSTRACT: Lactobacilli are probiotics that, among other health promoting effects, have been ascribed immunostimulating and virus preventive properties. Certain lactobacilli species have been shown to possess strong IL-12 inducing properties. As IL-12 production depends on the up-regulation of type I interferons, we hypothesized that the strong IL-12 inducing capacity of L. acidophilus NCFM in murine bone marrow derived DC is caused by an up-regulation of IFN-β, which subsequently stimulates the induction of IL-12 and the dsRNA binding toll like receptor (TLR)-3. The expression of the genes encoding IFN-β, IL-12, IL-10 and TLR-3 in DC upon stimulation with L. acidophilus NCFM was measured. L. acidophilus NCFM induced a much stronger expression of ifn-β, il-12 and il-10 compared to the synthetic d

ORGANISM(S): Mus musculus

SUBMITTER: Simon Rasmussen 

PROVIDER: E-GEOD-18460 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress