Discovery of biomarker genes form earthworm microarray data

ABSTRACT: Motivation: Monitoring, assessment and prediction of environmental risks that chemicals pose demand rapid and accurate diagnostic assays. A variety of toxicological effects have been associated with explosive compounds TNT and RDX. One important goal of microarray experiments is to discover novel biomarkers for toxicity evaluation. We have developed an earthworm microarray containing 15,208 unique oligo probes. Our objective was to identify biomarker genes that can separate earthworm samples into three groups: control, TNT-treated, and RDX-treated. Results: We developed a discriminant analysis and cluster (DAC) pipeline to analyze a 248-array dataset. First, a total of 869 significantly changed genes in response to TNT or RDX exposure were inferred by class comparison statistical algorith

ORGANISM(S): Eisenia fetida

SUBMITTER: Edward Perkins 

PROVIDER: E-GEOD-18495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress