DNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue

ABSTRACT: Progenitor cells maintain self-renewing tissues throughout life by sustaining their capacity for proliferation while suppressing cell cycle exit and terminal differentiation. DNA methylation provides a potential epigenetic mechanism for the cellular memory needed to preserve the somatic progenitor state through repeated cell divisions. DNA methyltransferase 1 (DNMT1) maintains DNA methylation patterns after cellular replication. Although dispensable for embryonic stem cell maintenance, a clear role for DNMT1 in maintaining the progenitor state in constantly replenished somatic tissues, such as mammalian epidermis, is uncharacterized. Here we show that DNMT1 is essential for supporting epidermal progenitor cell function. DNMT1 protein was found enriched in undifferentiated cells, where it w

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Khavari 

PROVIDER: E-GEOD-18590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress