Expression analysis in yeast model of Huntington's disease (HD)

ABSTRACT: Expressing a mutant fragment of huntingtin (Htt) in yeast produces several HD-relevant phenotypes. We used microarrays to study global change in expression induced by this mutant htt fragment. Expression was also analysed in three suppressor deletion strains expressing a toxic mutant htt fragment: bna4Δ, mbf1Δ, and ume1Δ. Yeast samples expressing either a wild-type or mutant htt fragment (Htt25Q or Htt103Q, respectively), and suppressor deletion strains expressing Htt103Q: bna4Δ, mbf1Δ, and ume1Δ.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Eran Tauber 

PROVIDER: E-GEOD-18644 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress