Transcriptomics

Dataset Information

45

Expression analysis in yeast model of Huntington's disease (HD)


ABSTRACT: Expressing a mutant fragment of huntingtin (Htt) in yeast produces several HD-relevant phenotypes. We used microarrays to study global change in expression induced by this mutant htt fragment. Expression was also analysed in three suppressor deletion strains expressing a toxic mutant htt fragment: bna4Δ, mbf1Δ, and ume1Δ. Overall design: Yeast samples expressing either a wild-type or mutant htt fragment (Htt25Q or Htt103Q, respectively), and suppressor deletion strains expressing Htt103Q: bna4Δ, mbf1Δ, and ume1Δ.

INSTRUMENT(S): [YG_S98] Affymetrix Yeast Genome S98 Array

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Eran Tauber 

PROVIDER: GSE18644 | GEO | 2010-11-09

SECONDARY ACCESSION(S): PRJNA121577

REPOSITORIES: GEO

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