Gene Expression Profiles of PBMC Characterize Inflammation Stages in the Acute Lung Injury in Mice

ABSTRACT: Acute respiratory distress syndrome (ARDS) carries about a 50 percent mortality and is frequently associated with an infection (sepsis). Life-support treatment with mechanical ventilation rescues many patients, although superimposed infection or multiple organ failure can result in death. The outcome of a patient developing sepsis highly depends on the degree of pre-existing inflammation prior to the infection. In this study, we describe each stage of the inflammation process using a transcriptional approach and an animal model. Femelle C57BL6/J mice received an intraveinous oleic acid injection to induce an acute lung injury. PBMC expression patterns have been analyzed using a 9900 cDNA mouse microarray (MUSV29K). Our gene-expression analysis revealed marked changes in the immune and infl

ORGANISM(S): Mus musculus

SUBMITTER: Isabelle Lesur Kupin 

PROVIDER: E-GEOD-19030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress