Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways

ABSTRACT: Synovial fibroblasts in persistent inflammatory arthritis have been suggested to have parallels with cancer growth and wound healing, both of which involve a stereotypical serum response program. We tested the hypothesis that a serum response program can be used to classify diseased tissues, and investigated the serum response program in fibroblasts from multiple anatomical sites and two diseases. To test our hypothesis we utilized a bioinformatics approach to explore a publicly available microarray dataset including RA, OA and normal synovial tissue, then extended those findings in a new microarray dataset representing matched synovial, bone marrow and skin fibroblasts cultured from RA and OA patients undergoing arthroplasty. The classical fibroblast serum response program discretely clas

ORGANISM(S): Homo sapiens

SUBMITTER: Philipp Antczak 

PROVIDER: E-GEOD-56409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress