Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: C Vakoc
PROVIDER: E-GEOD-19155 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular cell 20091201 6
Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates active transcription in dividing cells, we investigated its role during M phase of the cell cycle. Unlike other chromatin-modifying enzymes examined, we found that MLL associates with gene promoters packaged within condensed mitotic chromosomes. Genome-wide location analysis identified a globally rearranged ...[more]