Dissection of human fibroblast populations by lung regions: genomic differences and functional pathway analysis

ABSTRACT: ABSTRACT Background: Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of alpha-SMA. The scope of the differences and the mechanisms driving them are unknown. We hypothesized that the distinct fibroblast characteristics based on lung region predicted a broad range of genomic differences which contribute to distinctly different functional pathway activation in AF and DLF. Methods and Findings: To investigate whether comprehensive gene expression patterns vary between AF and DLF, we compared global gene expression profiles of 3 matched pairs of primary human fibroblasts isolated from proximal and distal lung. 194 transcripts were upregulated in AF, and 290 transcripts upregulated in DLF

ORGANISM(S): Homo sapiens

SUBMITTER: XIUXIA ZHOU 

PROVIDER: E-GEOD-19362 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress