Gene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b

ABSTRACT: TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the induction of apoptosis, it is not well elucidated whether the each effect of TGF-b on T cells is dependent on Smad signaling or Smad-independent other signaling pathways. The aim of the study was to clarify the involvement of Smad signaling and to investigate the redundancy of Smad2 and Smad3 on various TGF-b-mediated regulation of gene expression in CD4+ T cells. We used microarrays to detail the global program of gene expression regulated by TGF-b in CD4+ T cells, and identified distinct classes o

ORGANISM(S): Mus musculus

SUBMITTER: Tomohito Takimoto 

PROVIDER: E-GEOD-19601 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress