Predicting Ventral Hernia Recurrence Through Genomic Profiling: An Observational Study

ABSTRACT: Patients with a history of recurrent ventral hernias (n=10) were compared with a control group (n=8) using high-throughput microarrays. Skin and fascia samples (taken away from the site of the ventral hernia) were analyzed from both groups. Our experiments show distinct genetic profiles between the skin and fascia of recurrent ventral hernia patients as compared to controls. There were also a great number of statistically significant genes in the skin as compared to the fascia. The functions of the genes in the skin were diverse and included wound healing, transcription regulation, and immunology. The genes in the fascia, however, were more specific concentrating primarily on immunology, regulation of gene expression and cellular metabolism, and development. Total RNA extracted from skin a

ORGANISM(S): Homo sapiens

SUBMITTER: J Davis 

PROVIDER: E-GEOD-19637 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress