Conditional Essentiality of vicK (walKSpn) Histidine Kinase for Anaerobic Growth of Streptococcus pneumoniae D39

ABSTRACT: The VicRK two-component system of S. pneumoniae (Pneumococcus) is a member of the essential WalRK (YycFG) family found in low G+C gram positive bacteria. Previously, we showed that phosphorylated VicR response regulator (RR) is essential, because of its strong positive regulation of the pcsB gene, which mediates cell division. Little is known about the signals sensed by the VicK or WalK histidine kinases (HK), and it is unknown why pneumococcal VicK is not essential under aerobic growth conditions, whereas other the WalK HKs in other species are essential. VicK contains the only PAS domain in the Pneumococcal genome. PAS domains in other HKs have been shown to sense oxygen or other metabolic signals, such as NAD+, and it has been speculated that VicK may be involved in sensing oxygen in S.

ORGANISM(S): Streptococcus pneumoniae

SUBMITTER: Ho-Ching Tsui 

PROVIDER: E-GEOD-19752 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress