Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Antisense miRNA-221/222 (si221/222) and control inhibitor (GFP) treated fulvestrant-resistant breast cancer cells

ABSTRACT: Full title: Expression data from antisense miRNA-221/222 (si221/222) and control inhibitor (GFP) treated fulvestrant-resistant breast cancer cells The expression of miR-221/222 were found to be upregulated in fulvestrant resistant breast cancer cells MCF7-FR compared to its drug-sensitive counterpart MCF7. To investigate the role of miR-221/222 in acquired resistance to fulvestrant, we lowered the level of miR-221/222 in MCF7-FR cells using miRNA inhibitors (antagomirs), and compared gene expression profiles before and after treatment. Fulvestrant-resistant breast cancer cells MCF7-FR (originated from drug-sentitive breast cancer model cell line MCF7) were transient-transfected by antigomirs targeting miR221 or miR222 (i.e. si221, si222). All three cell lines, MCF7-FR, siR221, siRNA222 were subjected to gene expression profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: Meng Li 

PROVIDER: E-GEOD-19777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways.

Rao X X   Di Leva G G   Li M M   Fang F F   Devlin C C   Hartman-Frey C C   Burow M E ME   Ivan M M   Croce C M CM   Nephew K P KP  

Oncogene 20101108 9

Fulvestrant is a selective estrogen receptor downregulator (SERD) and highly effective antagonist to hormone-sensitive breast cancers following failure of previous tamoxifen or aromatase inhibitor therapies. However, after prolonged fulvestrant therapy, acquired resistance eventually occurs in the majority of breast cancer patients, due to poorly understood mechanisms. To examine a possible role(s) of aberrantly expressed microRNAs (miRNAs) in acquired fulvestrant resistance, we compared antiest  ...[more]

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