Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state

ABSTRACT: We report the application of single molecule-based sequencing technology for high-throughput genom-wide mapping of MeCP2 binding and DNA methylation in mouse brain and cerebellum respectively. We find a good correlation between MeCP2 occupancy and methyl-CpG density and depletion of MeCP2 binding at CpG Islands, the majority of which are constitutively hypomethylated. This study provides a comprehensive characterisation of the genome wide distribution of MeCP2. Examination of MeCP2 occupancy in mouse brain and the distribution of methylation in mouse cerebellum.

ORGANISM(S): Mus musculus

SUBMITTER: Adrian Bird 

PROVIDER: E-GEOD-19786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress