Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
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ABSTRACT: We report the application of single molecule-based sequencing technology for high-throughput genom-wide mapping of MeCP2 binding and DNA methylation in mouse brain and cerebellum respectively. We find a good correlation between MeCP2 occupancy and methyl-CpG density and depletion of MeCP2 binding at CpG Islands, the majority of which are constitutively hypomethylated. This study provides a comprehensive characterisation of the genome wide distribution of MeCP2.
ORGANISM(S): Mus musculus
PROVIDER: GSE19786 | GEO | 2010/03/04
SECONDARY ACCESSION(S): PRJNA122117
REPOSITORIES: GEO
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