Expression profiling analysis of thymus and brain from EMP3 mutant mice

ABSTRACT: Background: Epithelial membrane protein 3 (EMP3) was previously reported to be involved in immunological reactions and in tumor as potential suppressor, as well as a candidate gene for cardiac dystrophic calcification (DCC). Given its assumed role in different disorders, we aimed to generate and perform a generalized phenotypic screening of EMP3-knockout mice. Materials and Methods: TaconicArtemis used knockout-targeting strategy and generated knockout mice for EMP3. Large-scale phenotype screens were performed at the German Mouse Clinic (GMC) to obtain a standardized and comprehensive way of phenotype. The phenotype screens involved tests for nearly 320 parameters in different screening areas such as: dysmorphology, behavior, neurology, eye, nociception, energy metabolism, clinical chemis

ORGANISM(S): Mus musculus

SUBMITTER: Marion Horsch 

PROVIDER: E-GEOD-19871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress