Expression profiling of lung tissue from 6-, 10- and 14-week-old Fra2 transgenic male mice

ABSTRACT: The transcription factor complex AP-1 (Activator protein 1) is composed of Jun (c-Jun, JunB, JunD) and Fos proteins (c-Fos, FosB, Fra-1, Fra-2) which control a variety of stress responses, including cell proliferation, apoptosis, inflammation, wound healing, and cancer. Individual Fos proteins have been thoroughly studied in gain- and loss-of-function mouse models, which revealed important functions in bone cell proliferation and differentiation. We have recently demonstrated that loss of Fra-2 causes perinatal lethality and severe osteopenia due to several cellular defects, including a chondrocyte differentiation defect and a control of osteoclast survival and size. Moreover, we have reported a profibrogenic function of Fra-2 in transgenic mice, in which ectopic expression of Fra-2 in var

ORGANISM(S): Mus musculus

SUBMITTER: Marion Horsch 

PROVIDER: E-GEOD-23745 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress