Effects of dietary obesity in fathers on gene expression of islets in the female offspring

ABSTRACT: The global prevalence of obesity is increasing across age and gender. The rising burden of obesity in young people contributes to the early emergence of type 2 diabetes. Having one parent obese is an independent risk factor for childhood obesity. While the detrimental impact of diet-induced maternal obesity on offspring is well established, the extent of the contribution of obese fathers is unclear, as is the role of non-genetic factors in the casual pathway. Here we show that paternal high fat diet exposure programmed β-cell ‘dysfunction’ in their F1 female offspring. Chronic high fat diet consumption in Sprague Dawley fathers led to increased body weight, adiposity, impaired glucose tolerance and insulin sensitivity. Relative to controls, their female offspring had lower body weight

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ruby Lin 

PROVIDER: E-GEOD-19877 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress